Abstract: Synthesis conditions of 2-mercapto benzothiazole by reacting aniline with carbon disulfide and sulfur were optimized with single factor optimization and response surface methodology (RSM). Based on the results of single factor optimization，optimal stirring mode and catalysts were obtained，and the effects of such factors as temperature rise rate，heat holding time and substrate ratio were studied with RSM. A mathematic model of yield for 2-mercapto benzothiazole was established，and the best conditions were obtained：high temperature，high pressure and no stirring，salicylic acid as catalyst，and the mass of salicylic acid 5% of aniline，substrates mole ratio of aniline：sulfur：carbon disulfide = 1∶1.05∶1.11，temperature rise rate 1.93℃/min，reaction time 2.0h. The maximum yield was 92.08% under the optimal conditions，reaction time was shortened to 1.0h，temperature rise rate was reduced by 0.77℃/min，and the yield was improved by 6.2%.

摘要： 采用单因素考察和响应面分析法相结合，对高压下苯胺、CS2和硫磺合成2-巯基苯并噻唑的工艺条件进行优化。首先单因素考察法优化了搅拌、催化剂两个因素，再采用响应面分析法对升温速率、保温时间、原料配比3个关键因素进行优化分析，得到了合成2-巯基苯并噻唑的收率计算模型，并得到合成优化条件：反应在高温高压无搅拌条件下，以水杨酸为催化剂，水杨酸用量为苯胺质量的5%，原料摩尔配比为n(苯胺)∶n(S)∶n(CS2)=1∶1.05∶1.11，升温速率为1.93℃/min，保温时间为2.0 h，2-巯基苯并噻唑收率高达92.08%，使得反应时间缩短1.0 h，升温速率降低了0.77℃/min，收率提高了6.2%。