Abstract: Obesity is the major factor inducing high blood lipid，fatty liver，diabetes，cardiovascular disease and so on. And it has become one of the important problems harming the health of people worldwide. In order to obtain a new low density lipoproteins (LDL) adsorbent，chitosan (CTS)，which is polycationic，was modified to prepare a polyanionic derivative. In this paper，based on Mannich reaction，a novel polyanionic chitosan derivative—N-methylene chitosan phosphate ester (NMCP)，was synthesized by introducing the phosphorous acid into the amido group of chitosan. The chemical structure and properties of NMCP was characterized with FT-IR，XRD and dynamic contact angle meter. The absorbability of CTS and NMCP with respect to lipoprotein was also studied.

摘要： 为了得到一种新型低密度脂蛋白吸附剂，将具有聚阳离子性质的壳聚糖（CTS）通过改性制备了一种聚阴离子衍生物。利用Mannich反应原理，在壳聚糖的氨基上引入了亚磷酸酯基，制备了新型阴离子型壳聚糖衍生物N-亚甲基壳聚糖亚磷酸酯（NMCP）。对衍生物的化学结构和性质通过FTIR、XRD和动态接触仪进行了表征，并研究了CTS和NMCP对脂蛋白的吸附性能。