Abstract: The optimum extraction process for simultaneous extraction of galanthamine and lycorine from Lycoris Herb. was studied with orthogonal design，and the influences of ethanol volume fraction，temperature，ratio of extracted material to solvent and time were investigated. Optimum extraction conditions were determined as follows: 75% ethanol at 65 ℃ in 4 hours and the solid to liquid ratio 1∶6 (g/mL)，extracting for three times. The extraction rates of total galanthamine and lycorine were 0.04793% and 0.03643% respectively .

摘要： 采用正交实验法对石蒜中加兰他敏和石蒜碱的一步法提取工艺进行研究，考察乙醇质量分数、提取温度、固液比及提取时间对石蒜中加兰他敏和石蒜碱得率的影响。结果表明，在浸提3次条件下，最佳工艺条件为：75%乙醇、提取温度65 ℃、提取时间4 h、固液比1∶6 (g/mL)，加兰他敏和石蒜碱的得率分别为0.04793%和0.03643%。