Abstract: (E)-1-phenylsulfonyl-2-methyl-4-hydroxy-2-butene（product A）was synthesized through the three-step process（addition，acetolysis and saponification）by using isoprene as the starting material and purified by crystallization from ether-ethyl acetate mixtures. 6-(4-phenylsulfonyl-3-methyl-2- butenyl)-2,3-dimethoxy-5-methylhydroquinone-O,O′-dibenzyl ether（product B）was synthesized by coupling reaction between hydroquinone and product A by using heteropoly acid as catalyst and with the hydroxyl group on hydroquinone protected by bromobenzyl. The end product B was purified by crystallization from ether-diisopropyl ether mixtures. The influence factors of the synthesis process were also studied. The yield of end product B was 75%（based on product A）. This process has distinct advantages，such as simple process，much milder reaction conditions，green chemical catalytic technology and so on. The structures of product A and end product B were identified by FTIR and 1H NMR.

摘要： 以异戊二烯为原料，经与苯磺酰氯加成、水解乙酰化、皂化3步反应，制得末端羟基取代的异戊二烯短侧链——（E）-1-苯磺酰基-2-甲基-4-羟基-2-丁烯（简称产物A），并用乙酸乙酯-乙醚混合溶剂对产物A进行提纯精制。以还原型辅酶Q0（氢醌）为母环，杂多酸为催化剂，与产物A进行偶联反应，然后采用溴化苄对母环羟基进行保护，用乙醚-异丙醚的混合溶剂进行提纯精制，选择性结晶得到了侧链延长法合成辅酶Q10的关键中间体辅酶Q1前体，即6-(4-苯磺酰基-3-甲基-2-丁烯)-基-2，3-二甲氧基-5-甲基氢醌双苄醚（简称产物B）。探讨了各主要影响因素对合成反应过程及结果的影响，目标产物B收率达75%（以产物A为基准）。产物A与目标产物B经测熔点、1H NMR分析和FTIR分析鉴定，确证其为（E）-异构体。