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Progress of synthesis techology of N-formylmorpholine

LIU Ruijiang,ZHANG Yewang,YU Xiaofeng   

  1. School of Pharmaceutics,Jiangsu University
  • Online:2008-05-05 Published:2008-05-05

N-甲酰吗啉的合成工艺研究进展

刘瑞江,张业旺,于小凤   

  1. 江苏大学药学院

Abstract: The advances in the synthesis of N-formylmorpholine are reviewed,and the properties and application as well as the synthesis methods,including formic acid method,methyl formate method,formyl chloride method,carboxide carbonylation of CO and supercritical CO2,morpholine and enamine oxidation method are presented and discussed in detail. The research trends of the synthesis of N-formylmorpholine are also analyzed.

摘要: 简要介绍了N-甲酰吗啉的性质和应用;详细综述了N-甲酰吗啉的合成工艺方法:甲酸法、甲酸酯法、甲酰氯法、CO和超临界CO2羰基化法、吗啉烯胺氧化法,并分析了各种方法的工艺特点;指出了N-甲酰吗啉合成工艺研究的趋势。

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