Abstract: In order to minimize the waste production in the conventional ammonolysis process of O,O-dimethylphosphorochloridothioate, some source reduction measures were developed，including using O,O-dimethylphosphorochloridothioate instead of benzene as extractant, improving the purity of the starting material O,O-dimethylphosphorochloridothioate，converting conventional batch STR reactor to a recycle tubular reactor，adopting more effective extraction equipment，optimizing operation conditions and using automatic control. At the same time，the wastewater was recycled and ammonia chloride was recovered in the ammonolysis process. These waste minimization measures have been implemented in an industrial process，leading to significantly less waste generation and much lower production cost.

摘要： 采用O,O-二甲基硫代磷酰氯代替苯作萃取剂，以提高O,O-二甲基硫代磷酰氯的质量分数；利用循环管式反应器取代传统的分批搅拌反应釜，改进废水萃取设备，采用自动控制、改进操作方式等源减少措施以及废水循环、反应结晶副产氯化铵等循环回收措施，对O,O-二甲基硫代磷酰氯氨解反应工业过程实施了废物最小化，降低了生产成本，大幅度减少了废物排放。