Abstract: This paper summarizes the study of the modeling and simulation of ethanol fermentation，and presents the characteristics of the models and the difficulty of simulation. The Monod equation could describe the competitive inhibitory actions well. The key problem of simulation is to optimize and solve the Monod equation. The Monod equation is converted into S system equations for optimization. The model here includes a mass transfer model. The difficulty of simulation is how to choose a proper overall transfer coefficient to simplify the solving process. And this simulation may perform the calculation of unstable equilibrium equations. Using cellulose as the substrate to produce ethanol is a new way to obtain ethanol at a low price. The mathematical model of the fermentation process should include the influences of polysaccharide decomposition and the inhibitory actions of the intermediate products. To simulate and optimize the ethanol fermentation process is helpful to decreasing ethanol production cost，and promoting commercial production. The direction of future study is to simulate the critical technique of cellulose fermentation and to compile application software，which is beneficial to optimization and automatic control.

摘要： 综述了乙醇发酵模型及模拟方面的研究，总结了各种模型的特点以及模拟的难点。Monod方程能较好地描述乙醇发酵的各种竞争性抑制作用，模拟的难点在于模型的优化求解；反应器中的乙醇发酵模型包括传质模型，模拟的难点在于采用总传质系数简化求解过程，并涉及非稳态平衡计算；纤维素发酵是大量制取廉价乙醇的方向，发酵模型中需综合考虑酶解、发酵及抑制作用等，模拟计算过程复杂。结果说明，对发酵过程进行模拟优化，是降低乙醇生产成本、促进乙醇大规模工业化生产的有效途径。提出乙醇发酵模型模拟方面的发展方向为：解决纤维素发酵的关键问题，并形成应用软件，有利于后续工业化中的优化控制等过程。