Abstract: A new method of modification for alginate-chitosan microcapsules with gold nanoparticles was reported. The gold-alginate-chitosan microcapsules were prepared with gold nanoparticles solutions. The optimum conditions of reactions and the particle size distributions of the gold-alginate-chitosan microcapsules were investigated. The value of pH=5.0 and reaction time of 120 minutes for reaction were chosen. The average diameters of the gold-alginate-chitosan microcapsules prepared respectively with citrate-stabilised gold nanoparticles and acrylate-stabilised gold ones were 216.686mm and 196.850 mm.

摘要： 制备了金-海藻酸钙-几丁聚糖微胶囊，提出了修饰用于蛋白质药物靶向传输的多糖载体-几丁聚糖的新方法，该方法通过在几丁聚糖微胶囊表面结合金的纳米微粒使微胶囊表面结构发生变化，从而改变微胶囊的性质，这种修饰方法目前未见报道。文中对制备条件进行了优化，并对金-海藻酸钙-几丁聚糖微胶囊的粒径分布进行了表征。文中选择在pH值为5时反应2 h，制得的柠檬酸体系和丙烯酸体系的金-海藻酸钙-几丁聚糖微胶囊的平均直径分别为216.686 mm和196.850 mm。