Abstract: A series of N-maleyl chitosan(N-MACH) with different degrees of substitution (DS) were synthesized by acylation. The DS，intrinsic viscosity and weight-average molecular weight of the products were calculated. The products were characterized with IR and NMR spectroscopy. Compared with hyaluronic acid(HA)，the sample with high DS value (M-11) which had high weight-average molecular weight and high intrinsic viscosity exhibited better moisture-absorption，moisture-retention and antibacterial characteristics，and had the potential to prepare HA-like substance. The result provided the experimental data for the widespread application of chitosan.

摘要： 通过酰化反应，制备一系列取代度不同的N-马来酰化壳聚糖。测定了产物的取代度、特性黏度、相对分子质量、吸湿保湿性，并用IR、NMR进行结构表征。研究发现高取代度高相对分子质量高黏度产物（M-11）的吸湿保湿性、抑菌性均优于透明质酸，有望替代昂贵的透明质酸，开辟壳聚糖新的应用范围。