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Research progress of pharmaceutical impregnation in supercritical CO2 condition and in-situ detection

YE Shuming；BAO Chengman；JIANG Chunyue   

  1. School of Life Sciences，Zhejiang University；School of Chemical Engineering and Materials Science，Zhejiang University of Technology
  • Online:2007-03-25 Published:2007-03-25

超临界CO2药物插嵌及在线检测研究进展

叶树明；鲍成满；蒋春跃   

  1. 浙江大学生命科学学院；浙江工业大学化工与材料科学院

Abstract: The mechanism and process of pharmaceutical impregnation，as well as cosolvent，in supercritical CO2 condition are introduced. On-line detection methods，especially weight measuring，volume measuring and in-situ spectroscopy are presented，The influence factors are also analyzed. The research progress in these fields is reviewed.

摘要： 介绍了SC-CO2条件下药物插嵌的机理、过程以及插嵌过程中助溶剂的研究情况，阐述了目前SC-CO2条件下药物插嵌的在线检测方法，主要包括称重法、测量体积法以及光谱检测法，分析了影响在线检测的因素，并且综述了目前有关药物插嵌以及在线检测的研究现状。

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