Abstract: 3-hydroxypropionic acid (3-HP) has many excellent chemical properties. It is an important potential compound for chemical engineering and a good intermediate to synthesize lots of valuable compounds. So far expensive and complex chemical methods to synthesize 3-HP have limited its use. This paper introduces the progress of producing 3-HP from glucose or glycerol by genetic engineering and microbial fermentation methods in the world.

摘要： 介绍了3-羟基丙酸的性质、用途及生产现状。3-羟基丙酸具有许多优良的化学性质，可以作为中间体合成多种有经济价值的工业用化合物，是一种潜在的重要化工平台产品；迄今为止，人们主要采用化学法合成3-羟基丙酸，但是该法成本较高，分离困难，限制了该化合物的应用。着重介绍了目前国外利用基因工程手段以葡萄糖或甘油为底物微生物发酵法生产3-羟基丙酸的研究进展，并探讨了今后的发展前景。