Abstract: High purity monochloroacetic acid was prepared by catalylic chlorination of acetic acid with chorine by using acetic anhydride as the catalyst, and concentrated H2SO4 as the co-catalyst. The optimal conditions of synthesis were as follows: acetic acid /Cl2/ acetic anhydride / H2SO4 is 1︰1.26︰0.08︰0.008, reaction temperature from 100 to 105℃. The purity of monochloroacetic acid can be up to 99%. This method has the advantages of abundant supply of raw materials, simple process, and easy operation.

摘要： 报道了以乙酸、氯气为原料，乙酐为催化剂，浓硫酸为助催化剂，通过催化精馏的方法连续化合成高纯度氯乙酸，物料配比m(乙酸)/m(氯气)/m(乙酐)/m(浓硫酸)为1/1.26/0.08/0.008，反应温度控制在100～105 ℃，产品氯乙酸纯度≥99%。本方法原料易得，工艺简洁，可操作性强。