Abstract: N, N-dilauryl chitosan with a high degree of substitution of alkyl group was prepared by reduction of the Schiff’s base，which was formed by the reaction of chitosan and aldehyde. The experimental results showed that only the product obtained from the reaction by adding sodium dodecyl sulfonate coulkd be separated into two parts of alkylated chitosan. One could not dissolve in chloroform，while the other could dissolve in chloroform. The product soluble in chloroform was found to be fully N, N-dilaurylated chitosan by FTIR，NMR and EA measurement.

摘要： 以十二烷基磺酸钠为相转移催化剂，通过月桂醛与壳聚糖反应形成Schiff碱，再用NaBH4还原合成N, N—双十二烷基化壳聚糖初产物。利用不同烷基化取代度的壳聚糖在氯仿溶剂中溶解度的差别，对初产物进行提纯，可溶于氯仿的产物的结构经红外光谱、核磁共振和元素分析等方法证明接近为完全N, N–双十二烷基化壳聚糖。