Abstract: Oxidation of toluene catalyzed by N–hydroxyphthalimide (NHPI)/transitions metals with molecular oxygen in the acetic acid reaction medium was reported. The effects of different M(acac)2 (M = Cu，Co，Ni，Fe，Mn) complexes on the oxidation were studied and the results showed that among theses transition metals manganese showed the highest catalytic activity. The effects of different manganese salts were also investigated，and MnCl2 had the highest activity. The reaction conditions of the oxidation process catalyzed by NHPI/ MnCl2 catalyst system were optimized. The optimum conditions were as follows：n(MnCl2)∶n(NHPI)=5×10－2，n(catalyst)∶n(toluene)=10.5%，V(acetic acid)∶V(toluene)= 1∶1，oxygen flow rate 0.05 L/min，reaction temperature 100 ℃ and reaction time 13 h. Under these conditions，61.0% benzoic acid could be obtained with 80.9% selectivity at 75.4% conversion.

摘要： 报道了以N–羟基邻苯二甲酰亚胺(NHPI)/过渡金属为催化剂，乙酸为反应介质，氧气为氧化剂，催化甲苯氧化。探讨了不同金属配合物M(acac)2 (M = Cu，Co，Ni，Fe，Mn)及不同阴离子对该催化体系催化性能的影响。结果表明不同过渡金属中反应活性最高的是Mn，不同的Mn盐中催化活性最高的是MnCl2；同时优化了NHPI/MnCl2催化体系的反应条件。最佳反应条件为：n(MnCl2)∶n(NHPI)=5×10－2、n(催化剂)∶n(甲苯)=10.5%、V(乙酸)∶V(甲苯)=1∶1、氧气流速为0.05 L/min、温度100 ℃、反应时间为13 h。在此条件下甲苯的转化率能达到75.4%，苯甲酸的选择性能达到80. 9%。