Preparation and antibacterial properties of chitosan biguanide hydrochloride complex with iodine

doi:10.16085/j.issn.1000-6613.2015.07.028

Abstract

Abstract: A novel derivative, chitosan biguanide hydrochloride (CGH), was synthesized by using chitosan (CTS) and dicyandiamide in a simple nucleophilic addition process at a certain temperature. Then, the complex compound (CGH-I₂) was obtained by immersing CGH in iodine ethanol solution with different concentrations. The properties of CGH were characterized by means of IR, XRD, TG and DTG. The analysis of iodine content shows that the maximum mass ratio of CGH complex with iodine was m (CGH):m (I₂) =1:0. 46 when the concentration of iodine ethanol solution was 0.02mol/L. The antimicrobial test results show that the antibacterial diameters of the CGH-I₂against E. coli and Staphylococcus aureus were (18±1)mm and (21±1)mm respectively, with a high sensitivity of bacteriostasis.

Key words: chitosan biguanide hydrochloride, iodine, complex, antibacterial, functional materials

摘要： 以壳聚糖(CTS)和双氰胺为原料, 在一定温度下通过亲核加成合成壳聚糖双胍盐酸盐(CGH)衍生物, CGH与不同浓度的碘乙醇溶液制备改性壳聚糖的碘络合物(CGH-I₂)。用IR光谱、XRD、TG和DTG对衍生物进行表征, 通过碘量法测CGH与碘络合的质量比。碘含量分析表明:碘乙醇溶液浓度为0.02mol/L 时, CGH与碘络合的最大质量比为m(CGH):m(I₂)=1:0.46。抑菌性测试表明:CGH-I₂对大肠杆菌和金黄色葡萄球菌抑菌环直径分别为(18±1)mm和(21±1)mm, 敏感度均为高度敏感。

关键词: 壳聚糖双胍盐酸盐, 碘, 络合, 抑菌, 功能材料

CLC Number:

O636.1

XU Ningning, XIE Linlin, TANG Yang, SAI Mingze, DING Derun. Preparation and antibacterial properties of chitosan biguanide hydrochloride complex with iodine[J]. Chemical Industry and Engineering Progree, 2015, 34(07): 1979-1982.

徐宁宁, 谢琳琳, 唐阳, 赛明泽, 丁德润. 壳聚糖双胍盐酸盐络合碘制备及抑菌性能[J]. 化工进展, 2015, 34(07): 1979-1982.

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