Abstract: Biosorption is regarded as a cost-effective biotechnology for the treatment of high volume and low concentration complex wastewater containing heavy metal(s). Saccharomyces cerevisiae is one of the promising biosorbents for heavy metal removal. In this paper，the main influence factors for the biosorption of Cd2+ by Saccharomyces cerevisiae are discussed. Results indicated that the pH value affects obviously the biosorption performance for Cd2+. The maximum biosorption capacity of unit biomass is reached at pH 4 for both the free and immobilized Saccharomyces cerevisiae，and the lower or higher pH values are not beneficial for the biosorption. The coexisting ions K+，Ca2+，Na+and Mg2+ have no obvious impact on the biosorption of Cd2+ by statistic analysis at low concentration. While when the concentration of any K+，Ca2+，Na+or Mg2+ ion is higher than 5 mg/L，the removal of Cd2+ would be affectted，and the impact sequence is K+＜Na+＜Ca2+＜Mg2+. The disturbing heavy metal ions Zn2+，Fe2+，Cu2+ and Pb2+ affect the biosorption of Cd2+，and the impact sequence is Pb2+< Zn2+< Fe2+< Cu2+. The competing impact of Cu2+ for the Cd2+ biosorption is most poignant in all disturbing heavy metal ions because Cd2+ ion is nearly not adsorbed at 50mg/L Cu2+ or higher.