Abstract: Nitration of 3-fluorophenyl acetic acid (1) was accomplished by heating it to 70 ℃ with nitro-sulfuric acid in dichloroethane for 4 h and 5-fluoro-2-nitrophenyl acetic acid (2) was obtained with 67.8% yield. The obtained compound (2) was treated with borane-tetrahydrofuran (B2H6–THF) complex under nitrogen atmosphere in excessive THF for 18 h to give a kind of dark brown oil，followed by ammonolysis with NH3·H2O in autoclave at 100 ℃ for 6 h to produce 2-(5-amino-2- nitrophenyl) ethanol (3) in 84.4% yield. Catalytic hydrogenation of (3) under 0.6～0.7 MPa. over 10% Pd/C in anhydrous isopropyl alcohol at 70～80 ℃ for 12 h produced 2-(2,5-diamino phenyl)ethanol (4) with 64% yield. Compared with the method reported in literature，the overall yield of target molecule (4) was increased by 11%. The chemical structure of (4) was determined by HPLC-MS and 1H-NMR.