Abstract: Progress in the catalysts for the synthesis of hexafluoroacetone through hexafluoropropylene oxidation in gas phase is summarized. Influences of catalyst preparation methods, varieties, structure and properties are reviewed, and the formation of active component and reaction mechanism are also introduced. It is indicated that the problems for hexafluoropropylene oxidation in gas phase are the much lower conversion of hexafluoropropylene and the much lower selectivity for hexafluoroacetone as well as the poor catalyst stability. It is presented that to develop new catalyst system in lowering the reaction activation energy and new promoter in maintaining the stability of active component are the main aims in future research works.