Abstract: Catalyst for C2 front-end hydrogenation was prepared via equality design methodology，and the composition and preparation technics were optimized. The prepared catalyst was compared with the commercially available catalyst in a simulating industry unit for 1000 h. It was proved that the activity of the prepared catalyst is slightly lower than that of the commercial one，while the prepared catalyst has a better selectivity. XPS analysis revealed that the prepared catalyst has a stronger effect with Pd-Ag alloy，and XRF analysis illustrated that the prepared catalyst has a less active composition on the catalyst surface.