Abstract:

In the investigation of resolution of racemic menthol，lipase is generally used because lipase has chemistry-，region-，and stereo-selectivity，and the operation with lipase is noted for reliable source，low-cost，and simple procedure. The research progress of racemic menthol resolution by lipase in the past 0 years is reviewed. Especially，potential industrial applications of the lipase catalytic approach and unit operations are covered by analyzing the processes of trans-esterification，hydrolysis reaction and influence factors. The optimal pathway of resolution is achieved by analyzing resolution routes of menthol and alternatives of acyl agent for trans-esterification of menthol. Future investigations of the resolution of racemic menthol by lipase are discussed.