Abstract:

Supported nickel（Ni/AC）was prepared by reduction of NiCl₂ with NaBH₄ in the presence of activated carbon. The catalyst（Ni/C）was characterized by SEM，TEM，and XRD. The effects of preparation and catalytic reaction conditions on catalytic activity were evaluated by using reductive amination of glucose with methylamine as a model reaction. The reaction product was analyzed by NMR. The glucose reacted with methylamine to form cyclo-methylamino-glucose，then was reduced under the action of the catalyst to form N-methyl-D-glucamine. The NaCl formed in the reduction preparation of the catalyst inhibited the catalytic reductive amination. The catalyst performance could be improved by adding triethylamine. The yield of N-methyl-D-glucamine was up to 98% at reaction temperature of 80 ℃，H₂ pressure of 5.0 MPa，molar ratio of glucose to Ni，glucose to MeNH₂ and glucose to Et₃N 9∶1；1∶1.8 and 1∶2.5，respectively.