化工进展

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对二甲氨基苯甲酸异辛酯的合成工艺

桂厚瑛,周秋名,胡新明,董留玉   

  1. 武汉理工大学理学院,湖北 武汉430070
  • 出版日期:2010-11-05 发布日期:2010-11-05

Synthesis of 2-ethylhexyl p-dimethylamiobenzoate

GUI Houying,ZHOU Qiuming,HU Xinming,DONG Liuyu   

  1. Institute of Science,Wuhan University of Technology,Wuhan 430070,Hubei,China
  • Online:2010-11-05 Published:2010-11-05

摘要:

对合成对二甲氨基苯甲酸异辛酯的原始工艺进行了改进,获得了收率高、成本低、毒性小、污染少的合成工艺优化方法;可实现大规模工业生产。即以N,N-二甲基对氨基苯甲酸和异辛醇为原料,无需溶剂脱水,用对甲苯磺酸作为酯化催化剂,采用高负压的方法除去反应过程中生成的水,从而使正反应能够最大限度地进行,反应温度控制在110120 。重点讨论了无溶剂参与的酯化反应条件:反应温度110120 ,真空度0.095 MPa,反应时间6 h,对二甲氨基苯甲酸与异辛醇的摩尔比为13.5,以对二甲氨基苯甲酸计,产品收率为90%

Abstract:

2-Ethylhexyl p-dimethylamiobenzoate was synthesized with higher yieldlower cost and nontoxicitywhich is easier realized for large-scale industrial production. Dimethylamino benzoic acid and isooctanol were used as starting materials without any solvent by using p-toluenesulfonic acid as a esterification catalyst. The reaction proceeded as much as possible to remove the produced water under highly reduced pressureand the reaction temperature was controlled in a range between 110and 120. The reaction conditions of the esterification without solvent should be emphasized that the temperature was between 110 and 120 at a negative pressure of 0.095 MPa for 6h. The molar ratio of dimethyl-aminobenzoic acid with isooctanol was 13.5. 2-Ethylhexyl p-dimethylamiobenzoate yield was higher than 90% based ondimethyl-aminobenzoic acid.

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