Abstract: A new aldehyde-functionalized glycomonomer，1,2:3,4-Di-O-isopropylidene-6-O-(2’- formyl-4’-vinyl phenyl)-D-galactopyranose（IVDG），was designed and prepared by the reaction of 1,2:3,4-di-O-isopropylidene-6-O-(p-toluenesulfonyl)-D-galactopyranose（ITDG）with 2-hydroxy-5- vinylbenzaldehyde，and its structure was confirmed via elemental analysis，MS，and NMR spectroscopy. The radical polymerization of IVDG was successfully achieved using AIBN as initiator at 60 ℃ in THF. Removal of the protective isopropylidene group from the sugar residue in polyIVDG was carried out quantitatively using 88% formic acid at room temperature，yielding a novel polymer containing both galactopyranose and aldehyde functionalities. These amphiphilic polymers self-assembled into well-defined aldehydes-bearing polymeric micelles in aqueous solution without recourse to any surfactant. The hydrodynamic radius（Rh）of the micelles was 450nm by DLS in CONTIN algorithm. The micelles could be observed directly under TEM. The prepared nanospheres can potentially be applied in medicine and biotechnology.