Abstract: Polyurethane is very attractive in pervaporation separation for its nice permeability，selectivity and mechanical properties. This review presents the recent progress in polyurethane membranes used for pervaperation separation. Special emphasis is given to synthesis，structural characteristics and separation performance of polyurethanes with polybutadiene，polyester or polyether as the soft segments. Besides，three modification methods of blending，filling and grafting are discussed. Advantages and disadvantages of different polymer membranes are also summarized. Finally，prospects for the development of polyurethane pervaporation membranes are proposed.