Abstract: Single metal and multiple metals doped La-hexaaluminate were synthesized by reverse microemulsion in the system of water / Triton X-100 / n-hexanol / cyclohexane. The effects of doped elements on the phase，specific surface area and activity for methane combustion were investigated by means of XRD and BET. The results indicated that among LaMxAl12-xO19 catalysts，the catalyst with a Mn iron (x=1) was the best，The introduction of single Mn could improve the catalytic activity at a low temperature and make methane light-off temperature shift to a lower value; Single Fe doped La-hexaaluminate could make methane completely convert at a lower temperature; Fe and Mn doped La-hexaaluminate had the highest activity at both low temperature and high temperature; The stability of LaMnFeAl10O19 at a high temperature was also excellent.