Abstract: Progresses in the application of C5 fraction and the research of C5 fraction separation technology are reviewed. Characteristics of several important separation processes and some newly developed technologies，which are believed to have potentials with high energy efficiency and economic performance，are introduced，such as thermally coupled distillation，heat-integration，chemical absorption and membrane separation etc. The prospects for the separation technology of C5 fraction are discussed，such as optimization in technologies，energy saving and new extractant development etc.