Abstract: Al-based slurry catalysts using pseudo-boehmite as aluminum source were prepared by complete liquid phase technology, and the catalyst precursors Cu(NO3)2 and Zn(NO3)2 were dissolved in different solvents. The as-prepared catalysts were characterized by means of X-ray diffraction, N2 adsorption, Xray photoelectron spectroscopy and H2 temperature-programmed reduction. Performance of the catalysts was evaluated in a slurry reactor for the synthesis of dimethyl ether (DME) from syngas. Results indicated that different solvent has significant influence on the catalyst structure and performance. Using glycol as solvent, the catalyst shows a stable phase structure and largest pore diameter and pore volume, meanwhile, the catalyst has more reducible copper and can be easily reduced. Therefore, the catalyst shows enhanced CO conversation while keeping the DME selectivity unchanged.