2,3,4,6-四-O-乙酰基-β-D-吡喃葡萄糖的合成工艺改进

化工进展

2,3,4,6-四-O-乙酰基-β-D-吡喃葡萄糖的合成工艺改进

于小凤，孙玉

江苏大学药学院

出版日期:2010-02-05 发布日期:2010-02-05

Improved synthesis for 2,3,4,6-tetra-O- acetyl-β-D-glucopyranose

YU Xiaofeng，SUN Yu

School of Pharmaceutics，Jiangsu University

Online:2010-02-05 Published:2010-02-05

摘要/Abstract

摘要： 简单介绍了2,3,4,6-四-O-乙酰基-β-D-吡喃葡萄糖的地位和重要性，分析并选择了其合成路线：以D-吡喃葡萄糖为起始原料，经乙酰化、溴化、水解三步反应合成标题化合物。产品经1H-NMR分析确认为2,3,4,6-四-O-乙酰基-β-D-吡喃葡萄糖。并对各步反应条件进优化，溴化收率高达87.3%，比文献报道提高了14.0%，其总收率达到50.6%，比文献提高了约6.0%。同时该工艺路线更安全、环保，操作更加方便。

Abstract: The importance of 2,3,4,6-tetra-O-acetyl-β-D-glucopyranose was introduced briefly, and the synthetic route was analyzed and selected. The target compound was obtained by acetylation, bromination and hydrolysis of D-glucopyranose. Structure of the product was affirmed by 1H NMR. The synthetic process was optimized, with which the yield of bromination is as high as 87.3% and is 14% higher than before. The total yield of 2,3,4,6-tetra-O-acetyl-β-D-glucopyranose was 50.6%, which is about 6% higher than before. This improved synthese is more safe and more environmental benign.

于小凤，孙玉. 2,3,4,6-四-O-乙酰基-β-D-吡喃葡萄糖的合成工艺改进 [J]. 化工进展.

YU Xiaofeng，SUN Yu. Improved synthesis for 2,3,4,6-tetra-O- acetyl-β-D-glucopyranose[J]. Chemical Industry and Engineering Progree.