Abstract: Cu/Cr catalyst exhibits superior catalytic hydrogenolysis activity in glycerol hydrogenolysis to 1，2-propanediol for its efficient hydrogenolytic activity towards C—O bond and poor activity towards C—C bond. Cu/Cr catalysts were prepared by different methods and examined for the glycerol hydrogenolysis reaction. Experimental results indicated that preparation methods have large effects on the glycerol hydrogenolysis. Among five catalysts prepared，the catalytic hydrogenolysis activity was found in the order of copper ammonia complexation method > Adkins method > sodium carbonate method > diatomite impregnation method > dry-mixed method. XRD，TG，BET，FT-IR and TPR were used to measure and analyse the structural differences of catalysts prepared by different methods. The correlation and structural effect with catalytic performance were also analysed and discussed.