Abstract: The product in the production of γ-decalactone by biological pathway has obvious toxicity to the growth of Yarrowia lypolitica.Resin AB-8 was added to adsorb converted product to reduce the toxicity on Yarrowia lypolitica.The optimum conditions were castor oil 25g/L，7.5% AB-8，pH 7.5. The maximal specific γ -decalactone formation rate increased by 36% and decreased slowly after it reached a maximum，leading to better product accumulation. The total product concentration reached 2.17g/L after 56h. As a result，addition of resin not only increased the production but also separated the product.

摘要： 研究通过添加树脂AB-8吸附转化产物以降低高浓度产物对Yarrowia lypolitica细胞的毒性，进而提高产量。确定了蓖麻油添加量25 g/L、树脂量7.5%、pH值7.5的最佳优化工艺，产物的最大比生成速率提高36%且达到最大值后降低较慢，有利于产物积累，56 h后总产量达到2.17 g/L，耦合工艺在提高产量的同时又能较好地实现产物的分离。