Abstract:

Three kinds of O-quaternary ammonium-N,N-dialkyl chitosan（QADCS）with different alkylation lengths were prepared by a self-developed quaternary ammonium reagent，glycidyl ethyl trimethyl ammonium chloride ether. The products were characterized by FTIR，EA and ¹H NMR. The monolayers of the synthetic products were studied. It shows that QADCS can form stable monolayers. The collapse pressure（π_c），limiting molecular area（A_ex）and maximum compressibility modulus（C_s^－1_,max）of the QADCS monolayers increase with the hydrophobic side-chain length，and the monolayer of O-quaternized ammonium-N,N-dilalkyl chitosan is the most cohesive. The research provides a basis for studying the self-assembly properties and drug-loading performances of QADCS.

摘要：

采用自制的季铵化试剂环氧丙基乙基三甲基氯化铵醚，制备3个不同烷基化长度的O-季铵化-N，N-双烷基壳聚糖（QADCS），用FTIR、EA和¹H NMR对产物进行表征，并试验其单分子膜性质。结果表明，所制得的QADCS可以形成稳定的单分子膜，并且QADCS单分子膜的崩溃压、极限分子面积及最大压缩模量随着侧链长度的增长而增大，其中O-季铵化-N,N-双十二烷基壳聚糖单分子膜的凝聚力最强。为进一步研究QADCS的自组装性质及载药性能提供依据。