Abstract:

Polycaprolactone（PCL）three-dimensional（3D）scaffold with spherulite and nanofibrous was first fabricated by thermally induced phase separation from a ternary PCL/dioxane/water system. The effects of aging temperature，ratio of dioxane and water on the morphology of nanofibrous scaffolds were investigated. The results showed that aging temperature played a crucial role in forming the unique nanofibrous structure. A higher gelation temperature or a higher content of water in the mixed solvent system was not favorable for the spherulite -like  morphology of scaffold. Coalescence of nanofibers occurred，even spherulite -like structure disappeared at a gelation temperatures higher than 8℃ or lower than －40℃ and at a proportion of water exceeding 12%.

摘要：

以二氧六环/水为溶剂体系采用相分离方法首次成功制备了高孔隙率、具有纳米纤维状结构的聚己内酯（PCL）支架，并且支架是以球体为结构单元的基体。文中主要探讨了陈化温度和溶剂比例对于球状纳米纤维结构支架形成的影响，太低（—40 ℃）或太高的陈化温度（≥8 ℃）均不利于PCL纳米纤维结构的出现，只有适宜的实验温度才可以得到纳米纤维球状基体。同样，非溶剂比例越大越不利于纳米纤维球状基体的形成。