Chemical Industry and Engineering Progree

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Progress of synthesis of (R)-2-chloromandelic acid

QIAN Jing,XU Saizheng,XUE Yaping,ZHENG Yuguo,SHEN Yinchu   

  1. Institute of Bioengineering,Zhejiang University of Technology,Hangzhou 310014,Zhejiang,China
  • Online:2011-02-05 Published:2011-02-05

(R)-邻氯扁桃酸的制备技术进展

钱 晶,徐赛珍,薛亚平,郑裕国,沈寅初   

  1. 浙江工业大学生物工程研究所,浙江 杭州 310014

Abstract:

(R)-2-chloromandelic acid is one of the most important intermediates and fine chemicals with broad use. It can be used for the synthesis of clopidogrelan anti-platelet drug that inhibits the ability of platelets to clump together as part of a blood clot. Presently(R)-2-chloromandelic acid can be prepared by asymmetric synthesis and resolution of racemate. This review introduces various preparation methods of (R)-2-chloromandelic acidand compares the advantages and disadvantages of these methods. The prospect of (R)-2-chloromandelic acid synthesis methods is also discussed.

摘要:

(R)-邻氯扁桃酸是一种具有广泛用途的药物中间体和精细化工产品,主要用于抗血小板聚集药物氯吡格雷的合成,其制备方法主要包括不对称合成法和光学异构体拆分法。本文主要(R)-邻氯扁桃酸的各种制备方法进行了介绍,并比较了不同制备技术的优缺点,最后对手性邻氯扁桃酸的催化合成前景进行了展望。

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