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Advance in intelligent hydrogels based on N,N ′-dimethylaminoethyl methacrylate

LIAO Liewen,GONG Tao,ZHOU Jing,ZHOU Xinhua,CUI Yingde   

  1. Institute of Green Chemical Engineering,Zhongkai University of Agricultural and Engineering,Guangzhou 510225,Guangdong,China
  • Online:2011-02-05 Published:2011-02-05

DMAEMA系列智能水凝胶的研究进展

廖列文,龚 涛,周 静,周新华,崔英德   

  1. 仲恺农业工程学院绿色化工研究所,广东 广州 510225

Abstract:

Hydrogels can respond to the environmental changes by recognizing and then self-working under slight stimulation of physical and chemical environmentsuch as temperaturepH degreeionic strengthelectric fieldmagnetic fieldlightpressureetc. Tertiary amine group and double bondswhich exist in DMAEMAcan be protonated in acid medium. Its copolymers and homopolymers can be rendered pH sensitive and temperature sensitive by this propertywhich can be used in controlled drug releasetissue cultureenergy conversion deviceartificial muscleschemical valve and bionic actuator. In this paperbased on pHtemperature and electrical sensitivitythe recent research on DMAEMA sensitive hydrogels is reviewed. At lastthe applications in the fields of controlled drug release of such DMAEMA intelligent hydrogels are also presented.

摘要:

智能水凝胶对于环境微小的物理化学刺激,如温度、pH 值、离子强度、电场、磁场、光、压力等能够通过感知和自身作功来响应外界环境变化。甲基丙烯酸N,N-二甲氨基乙酯(DMAEMA)结构中,既含有叔胺基又含有可聚合的双键,在酸性介质中可以被质子化,因而其均聚物或共聚物具有一定的pH值敏感性,同时又具有一定的温敏性,有望在药物控释、组织培养、能量转换装置、人工肌肉、化学阀和仿生驱动器等领域得到新的应用。本文从pH值敏感性、温度敏感性、电场敏感性方面对近年来已见报道的DMAEMA系列敏感水凝胶的研究进行了较为详细的综述。同时,对DMAEMA系列智能水凝胶的响应性因素以及其在医药控释方面的应用作了相应的介绍。

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