Abstract:

Synthesis of 4-chlorophthalic anhydride（acid）was investigated based on D-A cyclization and aromatization. Two synthetic routes for 4-chlorotetrahydrophthalic anhydride，and its two aromatizing ways were optimizated and compared. The yield of 4-chlorotetrahydrophthalic anhydride was increased to 95% with purity higher than 98%. The aromatization yield using liquid bromine as the aromatizing reagent was increased to 89% with 99% purity；and the aromatization yield using oxygen and activated carbon as the aromatizing reagent was increased to 70% with 100% purity.

摘要：

为了寻找一条高效率合成4-氯代苯酐的路线，基于D-A环合原理和芳构化方法，首先，优化并比较了两条合成4-氯代四氢苯酐（二酸）的路线，然后，优化并比较了两条将4-氯代四氢苯酐（二酸）芳构化合成4-氯代苯酐的路线。得到如下结果：4-氯代四氢苯酐收率提高到95%，纯度大于98%；用液溴作芳香化试剂4-氯代苯酐的单步收率达到89%、纯度99%，氧气活性炭作芳香化试剂，4-氯代苯酐收率达到70%、纯度100%。