Abstract: As a kind of multi-copper oxidases，laccase can catalyze the polymerization of phenolic，aromatic compounds with amino groups，and some bioactive substances with the concomitant reduction of oxygen to water in a four-electron transfer process. Accordingly，researchers have paid increasing attention to the catalytic mechanisms and applications of laccases. This review provides a brief discussion about the catalytic structure and applications of laccases in organic synthesis. The characteristics of structure，redox potential and its influencing factor，and laccase-mediator system are dedicated in the structure part. The homo- and co-polymerizations，cross-coupling oxidation，and non-phenolic substrates oxidized by laccase-mediator system were emphasized in the organic synthesis category. Finally，the current research and perspective of laccase in organic synthesis are discussed.

摘要： 漆酶是一种含铜的多酚氧化酶，可催化酚类、芳胺类等单体聚合，也可催化合成多种具有生物活性的物质，且唯一的副产物是水，因其催化过程对环境污染小而受到青睐。本文综述了漆酶的催化结构特征、生产现状及其在有机合成中的应用，着重探讨漆酶结构上的特征和漆酶氧化还原电势的影响因素，以及漆酶介质体系中的反应机理；分类介绍了漆酶催化的聚合反应、酚类和芳胺类底物及非酚类底物的氧化反应。并对目前漆酶的研究现状和发展趋势进行了评述。