Abstract: In commercial production，hexanediamine (HDA) is derived from the hydrogenation (reduction) of adiponitrile (ADN)，which is mainly produced from butadiene (BD). According to synthesis methodology，the BD based preparation of ADN and/or HDA can be classified into four methods，i.e.，direct catalytic hydrocyanation of BD to ADN，chlorination-metal cyanation of BD to ADN，thermal dehydration of carboxylic acids with ammonia or of amide，and direct synthesis of HDA via adipic dialdehyde. This review discusses fundamental technical aspects and chemical reaction mechanisms in these synthesis methodologies，and provides comparison.

摘要： 工业生产中己二胺基本由己二腈（AND）加氢还原来制备，后者主要由丁二烯为原料生产。根据合成路线的不同，具有工业价值的由丁二烯合成己二腈和/或己二胺的方法可划分为4种：丁二烯直接催化氢氰化法合成ADN，丁二烯氯化-金属氰化法合成ADN，羧酸、氨热脱水法合成ADN及HMDA，丁二烯经己二醛合成HMDA。本文将论述上述合成方法的技术要点和涉及的化学反应机理，并对各个方法进行比较。