Abstract: The method of butyramide synthesis through hydration reaction of butyronitrile with water was studied. It was found that the highest activity of that Cr/Cu catalyst was obtained when the molar ratio of NaH2PO2/CuSO4 was 1.50—1.60 and that of Cr/Cu was 0.004—0.006 at the highest reaction temperature range of 55—57 ℃. The experimental results showed that the conversion rate of butyronitrile was up to 100% under the optimal reaction condition of the feed molar ratio of butyronitrile and water 1∶4.8，Cr/Cu catalyst concentration 22%—25%, reaction temperature 95—100 ℃ and residence time 5—6 h. In the experimental production conducted by the new process flow，the conversion rate of butyronitrile was 99% and the purity and yield of butyramide reached above 90 g·h－1 and 99.9% respectively.

摘要： 对正丁腈与水发生水合反应合成丁酰胺的方法进行了研究，在Cr/Cu催化剂制备过程中，当次磷酸钠与硫酸铜摩尔比为1.50～1.60、Cr/Cu摩尔比为0.004～0.006、最高反应温度控制为55～57 ℃时，所制备的Cr/Cu催化剂活性最高；正丁腈与水进料的摩尔比为1∶4.8，Cr/Cu催化剂浓度为22%～25%，反应温度为95～100 ℃，反应停留时间5～6 h，在此条件下，正丁腈的转化率接近100%；建立了丁酰胺生产工艺流程，在小试实验中，正丁腈的转化率为99%，丁酰胺产量90 g/h，丁酰胺的纯度达到了99.9%以上。