Abstract: Clindamycin phosphate as an antibiotic medicine is the third generation product of Lincomycin. It is widely used in clinical applications. Some compounds with similar structures in clindamycin phosphate raw material make the purification difficult．Nowadays，cooling combined with dilute crystallization is the most important technique to purify and obtain good crystalline quality of clindamycin phosphate. In this work，the solvent composition，cooling method and rate，stirring rate were investigated to disclose their influence on the quality including：purity，crystal size distribution，crystal size，content of residual solvent. The optimum operation conditions were provided.

摘要： 冷却与溶析的耦合结晶是目前克林霉素磷酸酯工业提纯的主要工艺，也是控制产品质量的的关键步骤。本文考察了克林霉素磷酸酯结晶过程中降温方式、搅拌速率和溶剂配比这3个主要操作因素对结晶质量的影响，包括纯度、粒度分布、溶剂残留等方面。研究结果表明，在实验研究范围内，溶剂配比为D、程序降温控制下，冷却速率为β4 或 β3、搅拌速率为300～400 r/min方案时可以得到质量最好的产品。