Abstract: ：Ozagrel，an anti-thrombosis drug，was synthesized from 4-methylbenzaldehyde by Claisen condensation with ethyl acetate to give ethyl 4-methyl cinnamate，then by bromination with NBS to give ethyl 4-bromomethyl cinnamate，which was condensed with imidazole in alkaline followed by hydrolysis. The optimum process parameters were also determined with an overall yield of 41.6%.

摘要： 研究了以4-甲基苯甲醛为原料，经克莱森缩合、N-溴代丁二酰亚胺（NBS）溴化、咪唑缩合以及碱条件下水解反应制得抗血栓药奥扎格雷的工艺。考察了反应物配比、温度控制、NBS用量、缩合反应碱的选择、水解碱用量控制等因素的影响，4步反应总收率为41.6%。