Abstract:

Linear polysulfide (P1) with a vinyl side group was obtained by ring-opening polymerization of 1-allyl oxygen-2,3-cyclothiopropane, which was then water-soluble by the introduction of sufficient carboxyl group by thiol-olefin click. Modified linear polysulfide (P2) reduced silver nitrate in situ to silver nanoparticles (Ag NPs), which was used as antibacterial agents. TEM test showed that Ag NPs were successfully prepared with the particle size of 5—20nm. Moreover, XPS analysis proved that Ag NPs formed a silver-sulfur coordination bond with sulfur element in P2 polymer chain. The composite crosslinking agent (Ag NPs@P2) was formed by the Ag-S coordination of P2 and Ag NPs, and with the initiation of potassium persulfate (KPS), the antibacterial hydrogel was prepared by free radical polymerization with acrylamide (Am) and Ag NPs@P2. The antibacterial experiments on Escherichia coli indicated that Ag NPs@P2/PAm had the synergistic antibacterial capability, and Ag NPs@P2 loaded with mass fraction of 2% had the best bacteriostatic effect. The hydrogels overcome the resistance problem of traditional antibiotic hydrogels and the poor compatibility of inorganic and organic components, and provided a new strategy for the design of novel synergistic antibacterial hydrogels.

Key words: silver-sulfur coordination, synergistic antibacterial, silver nanoparticles, hydrogels

摘要：

1-烯丙氧基-2,3-环硫丙烷开环聚合得到侧基带乙烯基的线型聚硫醚（P1），通过巯-烯click反应引入足够量的羧基，赋予其水溶性。修饰后的线型聚硫醚（P2）将硝酸银原位还原成银纳米颗粒（Ag NPs），将其用作抗菌剂。TEM测试表明成功制备出粒径尺寸为5~20nm的Ag NPs；且XPS分析证明了Ag NPs与P2聚合物链上的硫元素形成银-硫配位键。P2与Ag NPs通过银-硫配位作用形成复合交联剂（Ag NPs@P2），在过硫酸钾（KPS）的引发下，再与丙烯酰胺（Am）进行自由基聚合制备抗菌水凝胶。对大肠杆菌进行抗菌实验，结果表明Ag NPs@P2/PAm具有协同抗菌的能力，且负载质量分数为2%的Ag NPs@P2抑菌效果最好。该水凝胶克服了传统抗生素水凝胶的耐药性问题以及无机/有机组分相容性差的缺陷，为设计新型协同抗菌水凝胶提供了一种全新的策略。

关键词: 银-硫配位, 协同抗菌, 银纳米颗粒, 水凝胶