Research progress in cleaner production and resource utilization for diosgenin

doi:10.16085/j.issn.1000-6613.2015.03.039

Abstract

Abstract: Traditional diosgenin production process is simple in technique and easy to operate, but it has significant disadvantages, such as low yield, high energy consumption and environmental pollution. This paper summarized latest research progress in cleaner diosgenin production process, and emphasized the improved process of traditional inorganic acid hydrolysis and the process of non-inorganic acid hydrolysis. Techniques of non-inorganic acid hydrolysis were analyzed in more detail, such as ion exchange resin catalysis, ionic liquid catalysis, biotransformation and thermolysis. The advantages and disadvantages of different processes were compared. The improved process of traditional inorganic acid hydrolysis can increase diosgenin yield and reduce environmental pollution by certain amount, but wastewater and waste residue can still be a problem. The process of non-inorganic acid hydrolysis could have zero pollution, but the shortcomings of low yield and high cost could limit its development. This paper also outlined comprehensive utilization of wastewater and waste residue from producing diosgenin by using Dioscorea zingiberensis C. H. Wright, and summarized the problems in cleaner production process and the utilization of waste residue. The priority of future research was proposed to focus on increasing diosgenin yield in the process of non-inorganic acid hydrolysis, exploring and developing resource utilization of waste residue.

Key words: diosgenin, Dioscorea zingiberensis C. H. Wright, hydrolysis, catalysis, waste treatment

摘要： 现有的薯蓣皂素传统生产工艺具有工艺简单、易操作的优点, 但在产率、能耗及环境污染等方面存在较大问题。本文综述了国内外薯蓣皂素清洁化生产工艺的研究进展, 介绍了两类清洁化生产工艺——传统无机酸水解改进工艺和非无机酸水解工艺, 着重概述了发展前景较好的非无机酸水解工艺, 包括离子交换树脂催化法、离子液体催化法、生物转化法以及热分解处理法, 并比较了不同工艺的优缺点。指出传统无机酸水解改进工艺虽能减少无机酸对环境的污染, 大部分还能提高皂素产率, 但废水废渣的问题仍然没有解决;非无机酸水解工艺几乎零污染排放, 但存在产率低、成本高等不足。本文同时简述了从黄姜提取皂素过程中废水废渣的综合利用方法, 总结了清洁化生产工艺和废渣利用中存在的问题, 提出未来应以提高非无机酸水解工艺的皂素产率为研究重点, 并对废渣的资源化利用不断进行探索和开发。

关键词: 薯蓣皂素, 黄姜, 水解, 催化, 废物处理

CLC Number:

TQ467.8

SU Wei, GUO Wanping, LIU Zhenjie, CHEN Liuchan, WU Xiaoqun, YU Lin. Research progress in cleaner production and resource utilization for diosgenin[J]. Chemical Industry and Engineering Progree, 2015, 34(3): 840-847.

苏微, 郭万平, 刘振杰, 陈柳婵, 吴晓群, 余林. 薯蓣皂素清洁化生产工艺及资源化利用研究进展[J]. 化工进展, 2015, 34(3): 840-847.

References

[1] Unny R, Chauhan A K, Joshi Y C, et al.A review on potentiality of medicinal plants as the source of new contraceptive principles[J].Phytomedicine, 2003, 10(2-3):233-260.

[2] Xin G, Wang Y Y, Guo X R, et al.Synthesis of diosgenin-ibuprofen derivatives and their activities against insulin-dependent diabetes mellitus[J].Chemical and Pharmacentical Bulletin, 2013, 61(5):532-538.

[3] Tada Y, Kanda N, Haratake A, et al.Novel effects of diosgenin on skin aging[J].Steroids, 2009, 74(6):504-511.

[4] Man S L, Gao W Y, Zhang Y J, et al.Chemical study and medical application of saponins as anti-cancer agents[J].Fitoterapia, 2010, 81(7):703-714.

[5] Tong Q Y, He Y, Zhao Q B, et al.Cytotoxicity and apoptosis-inducing effect of steroidal saponins from Dioscorea zingiberensis Wright against cancer cells[J].Steroids, 2012, 77(12):1219-1227.

[6] Rajalingam K, Sugunadevi G, Vijayaanand M A, et al.Anti-tumour and anti-oxidative potential of diosgenin against 7, 12-dimethylbenz(a)anthracene induced experimental oral carcinogenesis[J].Pathology & Oncology Research, 2012, 18(2):405-412.

[7] Rothrock J W, Hammes P A, Mcalleer W J.Isolation of diosgenin by acid hydrolysis of sapogenin[J].Industrial & Engineering Chemistry Research, 1957, 49(2):186-188.

[8] 孙欣, 邓良伟, 吴力斌.皂素生产废水污染特点及治理现状[J].中国沼气, 2005, 23(1):25-28.

[9] 王俊, 陈钧, 杨克迪, 等.水解原位萃取薯蓣皂苷元的工艺条件研究[J].中国中药杂志, 2003, 28(10):934-937.

[10] 袁丽红, 邵辉, 顾永明, 等.盾叶薯蓣中水解原位提取薯蓣皂甙元[J].高校化学工程学报, 2007, 21(3):538-542.

[11] 毛楠, 黄文, 籍国东, 等.浸提分离法提取皂素清洁工艺研究[J].环境工程学报, 2009, 3(5):937-940.

[12] 杨欢, 杨克迪, 陈钧.双相酸水解法提取薯蓣皂苷元的研究[J].中国现代应用药学杂志, 2005, 22(4):270-272.

[13] Li X, Ma J Z, Xia J, et al.A study on the ultrasonic-assisted ethanol extraction of dioscin[J].Journal of Medicinal Plants Research, 2011, 5(14):2945-2951.

[14] Li X, Ma J Z, Xia J, et al.Study on the extraction of dioscin by the ultrasonic-assisted ethanol[J].African Journal of Biotechnology, 2014, 13(8):973-977.

[15] Li X, Ma J Z, X J.Study on extraction of dioscin from D.zingiberensis[J].Advanced Materials Research, 2011, 189-193:863-866.

[16] 杨转萍, 罗仓学, 李祥.超声波-表面活性剂协同萃取黄姜中薯蓣皂苷的工艺研究[J].食品科学, 2010, 31(22):46-49.

[17] Li X, Ma J Z, Xia J, et al.Surfactant assisted ethanol extraction of dioscin[J].Journal of Medicinal Plants Research, 2011, 5(3):324-331.

[18] 舒明勇.微波萃取法提取盾叶薯蓣皂苷元及含量分析[J].安徽农业科学, 2008, 36(31):13694-13696.

[19] 舒明勇.盾叶薯蓣皂苷元微波提取纯化及检测研究[J].广州化工, 2008, 36(5):35-39.

[20] 邹涛, 刘颋, 黄卫东, 等.微波法提取鲜黄姜总皂苷的工艺研究[J].化学与生物工程, 2012, 29(10):34-36.

[21] 刘琳, 董悦生, 修志龙.微波辅助双水相提取盾叶薯蓣中的皂苷成分[J].过程工程学报, 2009, 9(6):1147-1152.

[22] 曾云龙, 胡娅梅, 唐春然, 等.微波辅助乙醇-K2HPO4双水相提取黄姜总皂苷[J].应用化工, 2012, 41(1):13-15.

[23] 马俊林, 杨红琳, 胡菊, 等.微波-酶法处理超临界流体萃取黄姜皂素的研究[J].十堰职业技术学院学报, 2010, 23(5):94-96.

[24] 乔振杰, 李向民, 徐桂新.盾叶薯蓣中薯蓣皂甙元提取预发酵和水解条件的优化[J].西北农业学报, 2006, 15(3):212-215.

[25] 王喆, 王湘源, 邹煜平.黄姜皂素的提取新工艺[J].山地农业生物学报, 2006, 25(3):271-275.

[26] Peng Y E, Wang Y X, Yang Z H, et al.Content increase of spirostanol saponins during enzymatic hydrolysis of Dioscorea zingiberensis C.H.Wright[J].Industrial & Engineering Chemistry Research, 2010, 49(17):8279-8281.

[27] Zhang Y Q, Tang L R, An X, et al.Modification of cellulase and its application to extraction of diosgenin from Dioscorea zingiberensis C.H.Wright[J].Biochemical Engineering Journal, 2009, 47(1-3):80-86.

[28] 李辉, 倪晋仁, 张歆, 等.超临界CO₂ 提取黄姜中薯蓣皂甙元[J].精细化工, 2008, 25(11):1079-1082.

[29] 李水清, 王光忠, 肖锦, 等.超临界CO₂ 萃取盾叶薯蓣醇提物中薯蓣皂素[J].中国药师, 2009, 12(9):1194-1195.

[30] Yin L H, Xu Y W, Qi Y, et al.A green and efficient protocol for industrial-scale preparation of dioscin from Dioscorea nipponica Makino by two-step macroporous resin column chromatography[J].Chemical Engineering Journal, 2010, 165(1):281-289.

[31] 罗仓学, 杨转萍, 李祥.大孔树脂分离纯化黄姜中薯蓣皂苷工艺研究[J].食品科技, 2011, 36(5):229-232.

[32] 李谦, 高向涛, 徐俊清, 等.离子交换树脂催化薯蓣皂苷水解[J].应用化学, 2009, 26(4):431-434.

[33] Yan W, Ji L, Hang S, et al.New ionic liquid-based preparative method for diosgenin from Rhizoma dioscoreae nipponicae[J].Pharmacognosy Magazine, 2013, 9(35):250-254.

[34] Liu L, Dong Y S, Qi S S, et al.Biotransformation of steriodal saponins in Dioscorea zingiberensis C.H.Wright to diosgenin by Trichoderma harzianum[J].Applied Microbiology and Biotechnology, 2010, 85(4):933-940.

[35] Liu L, Dong Y S, Xiu Z L.Three-liquid-phase extraction of diosgenin and steroidal saponins from fermentation of Dioscorea zingibernsis C.H.Wright[J].Process Biochemistry, 2010, 45(5):752-756.

[36] Lei J, Niu H, Li T H, et al.A novel beta-glucosidase from Aspergillus fumigates releases diosgenin from spirostanosides of Dioscorea zingiberensis C.H.Wright (DZW)[J].World Journal of Microbiology & Biotechnology, 2012, 28(3):1309-1314.

[37] Zhu Y L, Huang W, Ni J R.A promising clean process for production of diosgenin from Dioscorea zingiberensis C.H.Wright[J].Journal of Cleaner Production, 2010, 18(3):242-247.

[38] Zhu Y L, Ni J R, Huang W.Process optimization for the production of diosgenin with Trichoderma reesei[J].Bioprocess and Biosystems Engineering, 2010, 33(5):647-655.

[39] Zhu Y L, Huang W, Ni J R, et al.Production of diosgenin from Dioscorea zingiberensis tubers through enzymatic saccharification and microbial transformation[J].Applied Microbiology and Biotechnology, 2010, 85(5):1409-1416.

[40] 陈俊英, 韩志慧, 刘国际, 等.无污染提取薯蓣皂素的热分解处理研究[J].农业科学, 2010, 43(18):3824-3830.

[41] Wang Y X, Liu H, Bao J G, et al.The saccharification-membrane retrieval-hydrolysis (SMRH) process:A novel approach for cleaner production of diosgenin derived from Dioscorea zingiberensis[J].Journal of Cleaner Production, 2008, 16(10):1133-1137.

[42] Peng Y E, Wang Y X, Yang Z H, et al.A two-stage nanofiltration process for reclamation of diosgenin wastewater[J].Desalination, 2010, 257(1-3):53-57.

[43] Li H, Ni J R, Liu W, et al.Cleaner production alternatives for saponin industry by recycling starch[J].Resources, Conservation and Recycling, 2010, 54(12):1145-1151.

[44] 周旋, 左淼, 邓光天.黄姜皂素工业固体废弃物的综合利用[J].武汉工程大学学报, 2012, 34(8):54-57.

[45] Zhang C X, Wang Y X, Yan X F.Liquid-phase adsorption:Characterization and use of activated carbon prepared from diosgenin production residue[J].Colloids and Surfaces A:Physicochemical and Engineering Aspects, 2006, 280(1-3):9-16.

[46] 李发永, 呼世斌, 郑志伟, 等.黄姜皂素生产废渣固态发酵纤维素酶产酶条件优化及酶学特性初探[J].西北农业学报, 2007, 16(6):277-281.

[47] 缪礼鸿, 毛义华, 朱薇玲.黄姜皂素废渣废水制备有机肥的研究与应用[J].湖北农业科学, 2007, 46(2):218-221.

[48] 缪礼鸿, 韩忠进.利用黄姜废渣制备微生物有机肥的研究[J].武汉工业学院学报, 2007, 26(1):1-3.

[49] 李美秀, 呼世斌, 王燕洁, 等.酸-菌-酶法处理黄姜皂素生产废渣的工艺[J].西北农业学报, 2010, 19(7):196-201.