化工进展 ›› 2016, Vol. 35 ›› Issue (03): 807-814.DOI: 10.16085/j.issn.1000-6613.2016.03.024

• 工业催化 • 上一篇    下一篇

金属-酶协同催化动态动力学拆分反应研究进展

蒋成君, 吕力琼, 黄俊   

  1. 浙江科技学院生物与化学工程学院, 浙江 杭州 310023
  • 收稿日期:2015-06-29 修回日期:2015-09-25 出版日期:2016-03-05 发布日期:2016-03-05
  • 通讯作者: 蒋成君(1981-),男,博士,高级工程师。E-mail:jcj312@163.com.
  • 基金资助:

    中国博士后科学基金(2014M551745)及浙江省自然科学基金(LY15B060008)项目。

Recent progress in dynamic kinetic resolution by metal catalysis cooperate with enzymes

JIANG Chengjun, LÜ Liqiong, HUANG Jun   

  1. School of Biological and Chemical Engineering, Zhejiang University of Science & Technology, Hangzhou 310023, Zhejiang, China
  • Received:2015-06-29 Revised:2015-09-25 Online:2016-03-05 Published:2016-03-05

摘要: 金属催化和酶催化在很长时间被认为是两个不同的领域,动态动力学拆分反应是金属-酶协同催化的成功应用。如何有效地协同金属催化的消旋化与酶催化的动力学拆分是其中的关键问题。本文对金属-酶协同催化动态动力学拆分醇和胺类化合物进行了综述,重点介绍了动态动力学拆分中常用的金属催化剂,各种金属与酶的协同,并对其前景进行了展望,指出提高酶在反应体系中的稳定性是未来的发展方向。

关键词: 生物催化, 动力学, 化学反应, 手性

Abstract: Enzyme and metal catalysis used to be considered as unconnected just like “two sides of a medal”. Chemoenzymatic dynamic kinetic resolution is an important application of metal complexes in cooperative catalysis with enzymes. The key point is how to cooperate racemization by metal and to conduct kinetic resolution by enzymes effectively. Racemization of a substrate with a metal complexes combined with a stereoselective transformation of the substrate catalyzed by an enzyme by kinetic resolutions dynamic was reviewed. The metal catalysts used in dynamic kinetic resolution and the coordination of various metals and enzymes were mainly introduced. In the final part of the perspective,improving the stability of enzyme in the reaction system is thought to be the future research direction.

Key words: biocatalysis, kinetics, chemical reaction, chirality

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